pyrK [Mon Jan 18 2016 15:50:42 GMT+0100 (CET)]

dihydroorotic acid dehydrogenase (electron transfer subunit)

locus: BSU15530

pI: 5.00

mw: 27.00 kDa

function: pyrimidine biosynthesis

product: dihydroorotic acid dehydrogenase (electron transfer subunit)

essential: no

synonyms: pyrDII, ylxD

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of nucleotides], [SW|most abundant proteins]

This gene is a member of the following [SW|regulons]

• [SW|PyrR regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,626,948 -> 1,627,718

The protein

Protein family

• FAD-binding FR-type domain (according to Swiss-Prot)

[SW|Cofactors]

• contains an iron-sulfur cluster

Expression and Regulation

Operon

• ''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|1709162]

Regulation

• induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]

Regulatory mechanism

• [protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]

Additional information

• belongs to the 100 [[most abundant proteins]] [PubMed|15378759]

References

• 8206849,8759868,1709162,10545205,15378759