petrobactin (3.4-catecholate siderophore) ABC transporter (binding protein), major component of the secretome
function
acquisition of iron
product
petrobactin ABC transporter (binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|acquisition of iron], [SW|iron metabolism], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|Fur regulon]Gene
Coordinates on the chromosome (coding sequence)
435,036 -> 435,989
The protein
Catalyzed reaction/ biological activity
uptake of the siderophore petrobactin [Pubmed|19955416]Protein family
Fe/B12 periplasmic-binding domain (according to Swiss-Prot)Structure
[PDB|3GFV][SW|Localization]
associated to the membrane (via [protein|search|YclN]-[protein|search|YclO]) [Pubmed|10092453,18763711]extracellular (signal peptide) [Pubmed|18957862][SW|Interactions]
[protein|search|YclP]-([protein|search|YclN]-[protein|search|YclO])-[protein|search|YclQ] [Pubmed|10092453]Expression and Regulation
Operon
''[protein|search|yclN]-[protein|search|yclO]-[protein|search|yclP]-[protein|search|yclQ]'' [Pubmed|19955416]Regulation
repressed unless the cells enter an iron starvation ([protein|search|Fur]) [Pubmed|12354229]Regulatory mechanism
[protein|search|Fur]: transcription repression [Pubmed|12354229]Additional information
the mRNA is cleaved by [rnc|search|RNase III] [PubMed|26883633]References
10092453,19955416,12354229,18957862,18763711,26883633 
