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dgrA [2017-03-21 15:25:56]
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dgrA [2017-03-21 15:25:56]

c-di-GMP receptor protein, inhibits motility at high c-di-GMP concentrations
locus
BSU22910
pI
7.88
mw
24.00 kDa
protein length
217 aa Sequence Blast
gene length
651 bp Sequence Blast
function
control of MotA activity
product
c-di-GMP receptor protein
essential
no
synonyms
ypfA,jofA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

Gene

Phenotypes of a mutant

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    • additional information

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    • Coordinates on the chromosome (coding sequence)
    2,397,019 -> 2,397,672

    RNA

    Catalyzed reaction/ biological activity

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    • additional information

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    • The protein

    Catalyzed reaction/ biological activity

  • [dddd]

    • Protein family

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    • Kinetic information

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    • [SW|Domains]

  • contains a C-terminal PilZ domain [Pubmed|22821967]

    • Modification

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    • [SW|Cofactors]

  • c-di-GMP [Pubmed|22821967]

    • Effectors of protein activity

  • binding of c-di-GMP stimulates the inhibitory interaction with [protein|86C729C7D5ABEE519ADC4A893940600BBB655EF1|MotA] [Pubmed|22821967]

    • Structure

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    • [SW|Localization]

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    • additional information

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    • categories

  • [category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.2|Targets of c-di-GMP]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.5|Additional chemotaxis signal transduction and regulatory proteins]
    • Expression and Regulation
    [[this]]

    Biological materials

    Mutant

  • MGNA-A419 (ypfA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/419 NBRP B. subtilis, Japan]

    • Expression vector

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    • lacZ fusion

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    • GFP fusion

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    • two-hybrid system

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    • FLAG-tag construct

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    • Antibody

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    • Labs working on this gene/protein

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    • References

    Reviews

  • 25251856

    • Original Publications

  • 23893111,22821967