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citM [Fri Dec 09 2016 17:17:45 GMT+0100 (CET)]
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citM [Fri Dec 09 2016 17:17:45 GMT+0100 (CET)]

Mg2 -citrate transporter
locus
BSU07610
pI
6.00
mw
45.00 kDa
function
uptake of citrate and magnesium
product
Mg2 -citrate transporter
essential
no
synonyms
yflO

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.4|Transporter for organic acids]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.1|Magnesium uptake/ efflux]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|transporters/ other], [SW|utilization of specific carbon sources], [SW|metal ion homeostasis (K, Na, Ca, Mg)], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|CitT regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    834,383 -> 835,684

    Phenotypes of a mutant

  • no growth with citrate as sole carbon source [Pubmed|10972810]
  • The protein

    Protein family

  • View classification (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|CitH]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|citM]-[protein|search|yflN]'' [Pubmed|10972810]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|10972810]
  • Regulation

  • induced by citrate ([protein|search|CitT]) [Pubmed|10972810]
  • repressed by glucose ([protein|search|CcpA]) [Pubmed|22900538,10972810]
  • Regulatory mechanism

  • [protein|search|CitT]: transcription activation [Pubmed|10972810]
  • [protein|search|CcpA]: transcription repression [Pubmed|22900538,10972810]
  • Biological materials

    Mutant

  • GP2244 (''[protein|search|citM]''::''ermC''), available in [SW|Jörg Stülke]'s lab
  • References

  • 16842348,11891560,10972810,11053381,3127276,12375105,8892821,12533460,12670692,11029430,12427932,22900538,24415722