response regulator aspartate phosphatase (RapC) regulator / competence and sporulation stimulating factor (CSF)
function
control of ComA activity
product
phosphatase (RapC) regulator /
competence and sporulation stimulating factor (CSF)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 6|Groups of genes] → [category|SW 6.8|Short peptides][SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|transcription factors and their control], [SW|quorum sensing], [SW|short peptides]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|CodY regulon], [SW|ComA regulon], [SW|SigH regulon]The protein
Catalyzed reaction/ biological activity
binds to [protein|search|RapC], this results in the inability of [protein|search|RapC] to interact with [protein|search|ComA] [Pubmed|12950917]Protein family
phr family (according to Swiss-Prot)Structure
[PDB|4GYO] (complex [protein|search|RapJ]-[protein|search|PhrC]) [Pubmed|23526881][SW|Interactions]
[protein|search|RapC]-[protein|search|PhrC] [Pubmed|12950917][protein|search|RapJ]-[protein|search|PhrC] [Pubmed|23526881]Expression and Regulation
Operon
''[protein|search|rapC]-[protein|search|phrC]'' [Pubmed|10464187]''[protein|search|phrC]'' [Pubmed|10464187][SW|Sigma factor]
rapC: [protein|search|SigA] [Pubmed|10464187]phrC: [protein|search|SigH] [Pubmed|10464187]Regulation
repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|10464187]repressed by glucose (4.5-fold) ([protein|search|CcpA]) [Pubmed|12850135]expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]Regulatory mechanism
[protein|search|ComA]: transcription activation ([protein|search|ComA]) [Pubmed|16091051][protein|search|CodY]: transcription repression [Pubmed|10464187][protein|search|CcpA]: transcription repression [Pubmed|12850135]References
Reviews
Original publications
12950917,16816200,19202088,18375560,11267663,10464187,12850135,16091051,23526881,22511326 
