phrC

response regulator aspartate phosphatase (RapC) regulator / competence and sporulation stimulating factor (CSF)

Locus: BSU_03780

Isoelectric point: 8.16

Molecular weight: 4.06 kDa

Protein length: 40 aa

Gene length: 123 bp

Function: control of ComA activity

Product: phosphatase (RapC) regulator / competence and sporulation stimulating factor (CSF)

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → Genetic competence
• Information processing → Regulation of gene expression → Transcription factors and their control → Control of two-component response regulators → Control of response regulators/ other
• Information processing → Regulation of gene expression → Quorum sensing
• Lifestyles → Exponential and early post-exponential lifestyles → Genetic competence
• Groups of genes → Short peptides

Gene

Coordinates: 429,963 → 430,085

The protein

Catalyzed reaction/ biological activity

• binds to RapC, this results in the inability of RapC to interact with ComA PubMed

Protein family

• phr family (according to UniProt)

Structure

• 4GYO (complex RapJ-PhrC) PubMed

Expression and Regulation

Operons

• Genes: rapC-phrC
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigH: sigma factor, PubMed, in SigH regulon

  Regulatory mechanism

  • CodY: repression, PubMed, in CodY regulon
  • ComA: activation, (ComA) PubMed, in ComA regulon
  • CcpA: repression, PubMed, in CcpA regulon

  Regulation

  • expressed at high cell density (ComA) PubMed

• Genes: phrC
  Description: PubMed

  Regulation

  • expressed at high cell density (ComA) PubMed

Biological materials

Mutant

• BKE03780 (ΔphrC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_ACTTAGATTTCAATTTCATA, downstream forward: _UP4_TAAGAACAAGCCCCTTCTCA
• BKK03780 (ΔphrC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_ACTTAGATTTCAATTTCATA, downstream forward: _UP4_TAAGAACAAGCCCCTTCTCA

References

Reviews

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Original publications

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