yetL [2020-04-13 16:30:15]

transcriptional repressor of [gene|A70EA4AEBF46ED2279E8BCE8A28439078484B6E3|yetM] and [gene|BFAFC2CFA7F2FDA639B367C579E2A46242BA3DBD|yetL], induction in response to flavonoids

locus: BSU_07220

pI: 7.52

mw: 19.07 kDa

protein length: 167 aa

gene length: 504 bp

function: regulation of [gene|A70EA4AEBF46ED2279E8BCE8A28439078484B6E3|yetM] expression

product: transcription repressor ([SW|MarR family])

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.10|Resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)]

Gene

Coordinates: 789,652 → 790,155

The protein

Protein family

• [SW|MarR family]

[SW|Domains]

• [SW|HTH marR-type domain] (aa 26-160) (according to UniProt)

Effectors of protein activity

• inducers: flavonoids of kaempferol, apigenin, and luteolin [Pubmed|19329649]

Expression and Regulation

Operons

• genes: [gene|BFAFC2CFA7F2FDA639B367C579E2A46242BA3DBD|yetL]
  description: [Pubmed|19329649]

Biological materials

Mutant

• MGNA-B463 (yetL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1462 NBRP B. subtilis, Japan]
• BKE07220 (Δ[gene|BFAFC2CFA7F2FDA639B367C579E2A46242BA3DBD|yetL]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE07220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCGCAATTAGCTCCCGTA, downstream forward: _UP4_TAAAAAACCCGTCCGATCCG
• BKK07220 (Δ[gene|BFAFC2CFA7F2FDA639B367C579E2A46242BA3DBD|yetL]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK07220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCGCAATTAGCTCCCGTA, downstream forward: _UP4_TAAAAAACCCGTCCGATCCG

References

Reviews

• 25209494

Original publications

• 19329649