SubtiBank SubtiBank
msrB [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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msrB [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

peptide methionine sulfoxide reductase
locus
BSU21680
pI
5.84
mw
16.00 kDa
function
regeneration of methionine and
restoration of protein function after oxidative damage
product
peptide methionine sulfoxide reductase
ec
1.8.4.12
synonyms
yppQ
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

    • [SW|Categories] containing this gene/protein

  • [SW|resistance against oxidative and electrophile stress]

    • This gene is a member of the following [SW|regulons]

  • [SW|Spx regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,287,097 -> 2,287,528

    The protein

    Catalyzed reaction/ biological activity

  • Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin (according to Swiss-Prot)

    • Structure

  • [PDB|1XM0]

    • Expression and Regulation

    Operon

  • ''[protein|search|msrA]-[protein|search|msrB]'' [Pubmed|18662407]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|18662407]

    • Regulation

  • induced by oxidative stress ([protein|search|Spx])

    • Regulatory mechanism

  • [protein|search|Spx]: oxidized Spx binds [protein|search|RpoA] and enhances ''[protein|search|msrA]-[protein|search|msrB]'' operon transcription [Pubmed|18662407]

    • References

  • 18662407