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rocR [Wed Mar 16 2016 17:54:16 GMT+0100 (CET)]
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rocR [Wed Mar 16 2016 17:54:16 GMT+0100 (CET)]

transcriptional activator of arginine utilization operons
locus
BSU40350
pI
6.00
mw
52.00 kDa
function
transcriptional activator of arginine utilization operons
product
transcriptional activator
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.4|Utilization of arginine/ ornithine]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

    • [SW|Categories] containing this gene/protein

  • [SW|utilization of amino acids], [SW|transcription factors and their control], [SW|glutamate metabolism], [SW|Transcription factors activating transcription at SigL-dependent promoters]

    • Gene

    Coordinates on the chromosome (coding sequence)
    4,145,747 -> 4,147,132

    The protein

    Catalyzed reaction/ biological activity

  • transcription activation at [protein|search|SigL]-dependent promoters of ''[rocA|search|rocABC]'', ''[rocD|search|rocDEF]'', and ''[protein|search|rocG]

    • Protein family

  • [SigL |search| Sigma-54] interacting transcription activator
  • [SW|Transcription factors activating transcription at SigL-dependent promoters]

    • [SW|Domains]

  • [SigL |search| Sigma-54] factor interaction domain (143–372)
  • 2x nucleotid-binding domain (171–178),(233–242)
  • HTH motif (434–453)
  • [SW|PAS domain]

    • [SW|Cofactors]

  • ornithine or citrulline are required for RocR-dependent transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/9194709 PubMed]

    • [SW|Interactions]

  • RocR-[protein|search|SigL]

    • Expression and Regulation

    Operon

  • ''rocR'' (according to [http://dbtbs.hgc.jp/COG/prom/rocR.html DBTBS])

    • [SW|Sigma factor]

  • [protein|search|SigA] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids= 7540694 PubMed]

    • Regulation

  • autoregulation by [protein|search|RocR] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids= 7540694 PubMed]

    • Regulatory mechanism

  • autorepression

    • Biological materials

    Mutant

  • QB5533 (aphA3), from [SW|Michel Debarbouille], available in [SW|Jörg Stülke]'s lab
  • 1A911 ( ''rocR''::''kan''), [Pubmed|16585774], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A911&Search=1A911 BGSC]
  • BKE40350 (''[protein|search|rocR]''::''erm'', available in the BGSC, in [SW|Fabian Commichau]'s, and in [SW|Jörg Stülke]'s lab)

    • Labs working on this gene/protein

  • [SW|Michel Debarbouille], Pasteur Institute, Paris, France [http://www.pasteur.fr/ip/easysite/go/03b-00000m-0ob/recherche/departements-scientifiques/microbiologie/unites-et-groupes/unite-de-biologie-des-bacteries-pathogenes-a-gram-positif/les-membres-de-l-equipe Homepage]

    • References

  • 12634342,8113162,9194709,21965396,23869754,21906631