imidazolone-5-propionate hydrolase
function
histidine utilization
product
imidazolone-5-propionate hydrolase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.5|Utilization of histidine][SW|Categories] containing this gene/protein
[SW|utilization of amino acids]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|CodY regulon], [SW|HutP regulon]Gene
Coordinates on the chromosome (coding sequence)
4,045,245 -> 4,046,510
The protein
Catalyzed reaction/ biological activity
(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate H2O = N-formimidoyl-L-glutamate H (according to Swiss-Prot) Protein family
hutI family (according to Swiss-Prot)Structure
[PDB|2BB0][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|hutP]-[protein|search|hutH]-[protein|search|hutU]-[protein|search|hutI]-[protein|search|hutG]-[protein|search|hutM]'' [Pubmed|10746760][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8071225]Regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|8071225]induced by histidine ([protein|search|HutP]) [Pubmed|8071225]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8682780]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|8071225][protein|search|CodY]: transcription repression [Pubmed|8682780][protein|search|HutP]: transcriptional antitermination at a protein-dependent [SW|RNA switch] located between ''[protein|search|hutP]'' and ''[protein|search|hutH]'' [Pubmed|8071225]References
Reviews
Original publications
10746760,8071225,8682780,10217782,16990261,27711543 
