yvmC [2017-8-11 16:0:3]

cyclodipeptide synthase

locus: BSU35070

pI: 6.61

mw: 28.36 kDa

protein length: 248 aa

gene length: 744 bp

function: biosynthesis of the extracellular iron chelate pulcherrimin

product: cyclodipeptide synthase

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]

Gene

Coordinates: 3,603,821 → 3,604,567

The protein

Catalyzed reaction/ biological activity

• synthesis of the cyclic dipeptide cyclo-L-leucyl-L-leucyl with the corresponding charged tRNAs as substrates in an ATP-dependent manner [Pubmed|19430487]

Structure

• [PDB|3S7T] (from ''B. licheniformis'', 70% identity, 86% similarity) [Pubmed|21325056]

Expression and Regulation

Operons

• genes: [gene|BCE1D8CDDF07396583FF50C4C192785545244BE2|yvmC]-[gene|D63EDBB6AA33708E8352F6208A9BA18CAEE0DC53|cypX]
  description: [http://www.liebertonline.com/doi/pdf/10.1089/ind.2006.2.66 Reference]

  regulatory mechanism

  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|20817675], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]
  • [protein|0D555F2AB7DC863E6FF388888308E980514DB719|PchR]: repression, in [regulon|0D555F2AB7DC863E6FF388888308E980514DB719|PchR regulon]

  regulation

  • expression of the operon is strongly induced at the beginning of [SW|biofilm formation] [pubmed|31113899]

References

• 19430487,420491,220817675,21325056,27542896