yvmC [Mon Aug 22 2016 16:00:48 GMT+0200 (CEST)]

cyclodipeptide synthase

locus: BSU35070

pI: 6.00

mw: 28.00 kDa

function: biosynthesis of the extracellular iron chelate pulcherrimin

product: cyclodipeptide synthase

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]

[SW|Categories] containing this gene/protein

• [SW|acquisition of iron], [SW|iron metabolism]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,603,821 -> 3,604,567

The protein

Catalyzed reaction/ biological activity

• synthesis of the cyclic dipeptide cyclo-L-leucyl-L-leucyl with the corresponding charged tRNAs as substrates in an ATP-dependent manner [Pubmed|19430487]

Structure

• [PDB|3S7T] (from ''B. licheniformis'', 70% identity, 86% similarity) [Pubmed|21325056]

Expression and Regulation

Operon

• ''[protein|search|yvmC]-[protein|search|cypX]'' [http://www.liebertonline.com/doi/pdf/10.1089/ind.2006.2.66 Reference]

Regulatory mechanism

• [protein|search|AbrB]: transcription repression [Pubmed|20817675]

References

• 19430487,420491,220817675,21325056