transcriptional antiterminator of the hut operon
function
regulation of histidine utilization
product
transcriptional antiterminator
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.5|Utilization of histidine][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.4|RNA binding regulators][SW|Categories] containing this gene/protein
[SW|utilization of amino acids], [SW|transcription factors and their control], [SW|RNA binding regulators]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|CodY regulon]The protein
Protein family
hutP family (according to Swiss-Prot)Effectors of protein activity
HutP binds its RNA target to cause antitermination in the presence of histidine [Pubmed|23748184]Structure
[PDB|3BOY] (complex bound to the hut mRNA), [PDB|1WPT]Expression and Regulation
Operon
''[protein|search|hutP]-[protein|search|hutH]-[protein|search|hutU]-[protein|search|hutI]-[protein|search|hutG]-[protein|search|hutM]'' [Pubmed|10746760][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8071225]Regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|8071225]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8682780]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|8071225][protein|search|CodY]: transcription repression [Pubmed|8682780]References
Reviews
17395359,16427271,22933560 
