response regulator aspartate phosphatase, dephosphorylates Spo0F-P
function
control of the phosphorelay
product
response regulator aspartate phosphatase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.2|Response regulator aspartate phosphatase][SW|Categories] containing this gene/protein
[SW|protein modification], [SW|phosphorelay], [SW|transcription factors and their control]The protein
Catalyzed reaction/ biological activity
dephosphorylates [SW|Spo0F]-P [Pubmed|21346797]Protein family
RAP family (according to Swiss-Prot)[SW|Domains]
RapJ is made up of the C-terminal tetratricopeptide repeat (TPR) domain that is connected by a flexible helix containing linker to the N-terminal 3-helix bundle. Upon binding of the regulating peptide [protein|search|PhrC], the 3-helix bundle and the linker helix undergo a conformational change to form a TPR-like fold that merges with the existing C-terminal TPR domain. [Pubmed|23526881]Effectors of protein activity
the interaction with [protein|search|PhrC] inactivates [protein|search|RapJ] [Pubmed|23526881]Structure
[PDB|4GYO] (complex [protein|search|RapJ]-[protein|search|PhrC]) [Pubmed|23526881][SW|Interactions]
[protein|search|RapJ]-[SW|Spo0F], dephosphorylation of [SW|Spo0F]-P [Pubmed|21346797][protein|search|RapJ]-[protein|search|PhrC] [Pubmed|23526881]Expression and Regulation
Operon
''rapJ'' (according to [http://dbtbs.hgc.jp/COG/prom/rapJ.html DBTBS])References
