required for normal spore cortex and coat synthesis, inhibits the proteolytic activity of [protein|search|FtsH ](adaptor protein)
function
spore cortex and coat synthesis
product
spore coat morphogenetic protein
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.1|Class I][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
1,655,446 → 1,655,526
Phenotypes of a mutant
reduction of sporulation efficiency due to defects in spore coat and cortex assembly [Pubmed|22463703]The protein
Catalyzed reaction/ biological activity
anchors the basement layer of the spore coat to the surface of the developing spore [Pubmed|22463703][SW|Domains]
contains an amphipathic alpha-helixStructure
[PDB|2MVH] [Pubmed|25825747][SW|Localization]
around the surface of the developing forespore [Pubmed|22463703]spore membrane, recognizes membrane curvature [Pubmed|19265022]spore coat (basement), localization depends on [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] [Pubmed|22171814]Expression and Regulation
Operons
genes
[gene|BBDA32A4EE3389D6F4404F7B3DA9E13AC7BF8055|spoVM]
description
[Pubmed|8231808]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|8231808,15699190], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]regulatory mechanism
[protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID]: activation, [Pubmed|8231808], in [regulon|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID regulon]regulation
expressed in mother cell during sporulation ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|8231808,15699190,19265022]view in new tabBiological materials
Mutant
BKE15810 (Δ[gene|BBDA32A4EE3389D6F4404F7B3DA9E13AC7BF8055|spoVM]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE15810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTGTCCCCTCCTATA, downstream forward: _UP4_TAATGCCCAGGGGTTCAAAGBKK15810 (Δ[gene|BBDA32A4EE3389D6F4404F7B3DA9E13AC7BF8055|spoVM]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK15810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTGTCCCCTCCTATA, downstream forward: _UP4_TAATGCCCAGGGGTTCAAAGReferences
Reviews
Original publications
10913836,18820968,8231808,9922240,19265022,12562810,9287010,17427285,19775244,15699190,22463703,22171814,22882210,25625300,25825747,25854653,29102609