cell wall-associated protein precursor, contact-dependent growth inhibition protein
function
intercellular competition
product
cell wall-associated protein precursor
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.18|Toxins, antitoxins and immunity against toxins/ based on similarity][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][SW|Categories] containing this gene/protein
[SW|cell wall/ other], [SW|toxins, antitoxins and immunity against toxins]This gene is a member of the following [SW|regulons]
[SW|DegU regulon], [SW|WalR regulon], [SW|YvrHb regulon]Gene
Coordinates on the chromosome (coding sequence)
4,023,544 -> 4,030,548
The protein
Catalyzed reaction/ biological activity
the C-terminal toxic domain has RNase activity (cleaves tRNAs) [Pubmed|23572593][SW|Domains]
cell wall binding domain as retention signalC-terminal toxic domain with RNase activity (cleaves tRNAs) [Pubmed|23572593]Effectors of protein activity
[protein|search|YxxG] inhibits the toxic activity of [protein|search|WapA] [Pubmed|23572593][SW|Localization]
extracellular (signal peptide), cell wall binding domain as retention signal, major constituent of the secretome [Pubmed|18957862][SW|Interactions]
[protein|search|WapA]-[protein|search|YxxG] [Pubmed|23572593]Expression and Regulation
Operon
''[protein|search|wapA]-[protein|search|yxxG]'' [Pubmed|16306698][SW|Sigma factor]
[protein|search|SigA] [Pubmed|23199363]Regulation
repressed at high salt concentration ([protein|search|DegU]-P) [Pubmed|9537385]Regulatory mechanism
[protein|search|DegU]-P: transcription repression [Pubmed|9537385]activated by [SW|YvrHb] [Pubmed|16306698][protein|search|WalR]: transcription repression [Pubmed|23199363]References
11987133,16672620,18957862,16306698,9537385,21821766,23572593,23199363,25666134 
