serine hydroxymethyltransferase
function
biosynthesis of glycine
product
serine hydroxymethyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.8|Biosynthesis/ acquisition of serine/ glycine/ alanine][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|essential genes], [SW|phosphoproteins], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|PurR regulon], [SW|T-box]Gene
Coordinates on the chromosome (coding sequence)
3,789,190 -> 3,790,437
Phenotypes of a mutant
essential [Pubmed|12682299]inactivation of ''[SW|glyA]'' suppresses the synthetic lethality of the ''[SW|defA] [SW|defB]'' double mutant [Pubmed|27983482]The protein
Catalyzed reaction/ biological activity
5,10-methylenetetrahydrofolate glycine H2O = tetrahydrofolate L-serine (according to Swiss-Prot) Protein family
SHMT family (according to Swiss-Prot)Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705], [Pubmed|17726680]Structure
[PDB|2VGU] (complex with L-serine, Geobacillus stearothermophilus), [PDB|2VI8] (Geobacillus stearothermophilus)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|glyA]'' (according to [http://dbtbs.hgc.jp/COG/prom/glyA.html DBTBS])[SW|Sigma factor]
[protein|search|SigA] [Pubmed|11591660]Regulation
repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]induced by glycine limitation ([protein|search|T-box]) [Pubmed|19258532]Regulatory mechanism
[protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532][protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750]Additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]References
19258532,11591660,20152942,19171795,17726680,16493705,15378759,27983482