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glyA [Mon May 16 2016 15:46:03 GMT+0200 (CEST)]
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glyA [Mon May 16 2016 15:46:03 GMT+0200 (CEST)]

serine hydroxymethyltransferase
locus
BSU36900
pI
5.00
mw
45.00 kDa
function
biosynthesis of glycine
product
serine hydroxymethyltransferase
essential
yes
ec
2.1.2.1
synonyms
glyC, ipc-34d
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.8|Biosynthesis/ acquisition of serine/ glycine/ alanine]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|essential genes], [SW|phosphoproteins], [SW|most abundant proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|PurR regulon], [SW|T-box]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,789,190 -> 3,790,437

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • 5,10-methylenetetrahydrofolate glycine H2O = tetrahydrofolate L-serine (according to Swiss-Prot)

    • Protein family

  • SHMT family (according to Swiss-Prot)

    • Modification

  • phosphorylated on ser/ thr/ tyr [Pubmed|16493705], [Pubmed|17726680]

    • Structure

  • [PDB|2VGU] (complex with L-serine, Geobacillus stearothermophilus), [PDB|2VI8] (Geobacillus stearothermophilus)

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|glyA]'' (according to [http://dbtbs.hgc.jp/COG/prom/glyA.html DBTBS])

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|11591660]

    • Regulation

  • repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]
  • induced by glycine limitation ([protein|search|T-box]) [Pubmed|19258532]

    • Regulatory mechanism

  • [protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]
  • [protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750]

    • Additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

    • References

  • 19258532,11591660,20152942,19171795,17726680,16493705,15378759