response regulator aspartate phosphatase, dephosphorylates Spo0F-P, control of the phosphorelay, control of ComA activity
function
control of sporulation initiation and ComA activity
product
response regulator aspartate phosphatase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.2|Response regulator aspartate phosphatase][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.5|Phosphatases controlling the phosphorelay][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.5|Phosphatases controlling the phosphorelay][SW|Categories] containing this gene/protein
[SW|protein modification], [SW|transcription factors and their control], [SW|phosphorelay], [SW|quorum sensing]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|ComK regulon], [SW|RghR regulon]Gene
Coordinates on the chromosome (coding sequence)
750,959 -> 752,089
The protein
Catalyzed reaction/ biological activity
binds to and thereby inhibits [protein|search|ComA] activity [Pubmed|17581123]RapH dephosphorylates [SW|Spo0F]-P and thereby controls the [SW|phosphorelay] [Pubmed|17581123]in addition to dephosphorylating [SW|Spo0F], RapH can antagonize sporulation by sterically blocking phosphoryl transfer to and from [SW|Spo0F] [Pubmed|21346797]Protein family
RAP family (according to Swiss-Prot)Effectors of protein activity
interaction with [protein|search|PhrH] inhibits dephosphorylation of [SW|Spo0F] and sequestration of [protein|search|ComA] by [protein|search|RapH] [Pubmed|21908671]Structure
[PDB|3Q15] ([protein|search|RapH]-[SW|Spo0F] complex) [Pubmed|21346797][SW|Interactions]
[protein|search|RapH]-[protein|search|ComA] [Pubmed|17581123][protein|search|RapH]-[SW|Spo0F]-P [Pubmed|17581123][protein|search|RapH]-[protein|search|PhrH] [Pubmed|21908671]Expression and Regulation
Operon
''[protein|search|rapH]-[protein|search|phrH]'' [Pubmed|21908671][SW|Sigma factor]
[protein|search|SigA] [Pubmed|21908671]Regulation
repressed by [protein|search|RghR] [Pubmed|16553878]Regulatory mechanism
[protein|search|RghR]: transcription repression [Pubmed|16553878][protein|search|ComK]: transcription activation [Pubmed|11948146,11918817][protein|search|AbrB]: transcription repression [Pubmed|20817675]References
16553878,17581123,11948146,11918817,20817675,21346797,21908671 
