choline dehydrogenase (FAD-dependent), glycine betaine synthesis
product
choline dehydrogenase (FAD-dependent)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.4|Biosynthesis of glycine betaine][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|coping with hyper-osmotic stress]This gene is a member of the following [SW|regulons]
[SW|GbsR regulon]The protein
Catalyzed reaction/ biological activity
An alcohol + NAD+ = an aldehyde or ketone + NADH (according to Swiss-Prot)Protein family
iron-containing alcohol dehydrogenase family (according to Swiss-Prot)Expression and Regulation
Operon
'' [protein|search|gbsA]-[protein|search|gbsB]'' [Pubmed|8752328][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8752328]Regulation
induced by choline ([protein|search|GbsR]) [Pubmed|22408163,8752328]Regulatory mechanism
[protein|search|GbsR]: transcription repression [Pubmed|22408163]Biological materials
Mutant
1A1056 ( ''gbsB''::''kan''), [Pubmed|21296969], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A1056&Search=1A1056 BGSC]Labs working on this gene/protein
[SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]References
8752328,21296969,22408163 
