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pyrB [Mon May 16 2016 17:10:50 GMT+0200 (CEST)]
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pyrB [Mon May 16 2016 17:10:50 GMT+0200 (CEST)]

aspartate carbamoyltransferase
locus
BSU15490
pI
5.00
mw
34.00 kDa
function
pyrimidine biosynthesis
product
aspartate carbamoyltransferase
essential
no
ec
2.1.3.2
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|PyrR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,620,476 -> 1,621,390

    The protein

    Catalyzed reaction/ biological activity

  • Carbamoyl phosphate L-aspartate = phosphate N-carbamoyl-L-aspartate (according to Swiss-Prot)

    • Protein family

  • ATCase/OTCase family (according to Swiss-Prot)

    • Modification

  • phosphorylation on Ser-303 [Pubmed|17218307]

    • Structure

  • [PDB|3R7D] [Pubmed|21663747]

    • Additional information

  • :
  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed]

    • Expression and Regulation

    Operon

  • ''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1709162]

    • Regulation

  • induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]

    • Regulatory mechanism

  • [protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]

    • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed]

    • References

  • 7868607,8206849,12896995,3015959,7840626,6427186,1709162,3937019,17218307,17322189,21663747