hprT [Tue Feb 14 2017 11:42:51 GMT+0100 (CET)]

trigger enzyme, hypoxanthine phosphoribosyltransferase and part of a transcription activator

Locus: BSU00680

Isoelectric point: 4.00

Molecular weight: 20.00 kDa

Function: purine salvage and interconversion, control of ftsH expression

Product: hypoxanthine phosphoribosyltransferase

Essential: no

E.C.: 2.4.2.8

Synonyms

Genomic Context

Loading

Categories containing this gene/protein

• Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Purine salvage and interconversion
• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
• Information processing → Regulation of gene expression → Transcription factors and their control → Control of transcription factor (other than two-component system)
• Information processing → Targets of second messengers → Targets of (p)ppGpp
• Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)

Categories containing this gene/protein

• biosynthesis/ acquisition of nucleotides, transcription factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes

This gene is a member of the following regulons

• SigM regulon

Gene

Coordinates on the chromosome (coding sequence): 76,344 -> 76,886

Phenotypes of a mutant

• essential PubMed, non-essential according to PubMed

The protein

Catalyzed reaction/ biological activity

• IMP diphosphate = hypoxanthine 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

Protein family

• purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)

Effectors of protein activity

• inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´PubMed

Structure

• 1J7J (from Salmonella typhimurium, 51% identity, 73% similarity)

Localization

• cytoplasm (according to Swiss-Prot)

Interactions

• TilS-HprT, the complex activates transcription of ftsH PubMed

Expression and Regulation

Operon

• tilS-hprT-ftsH PubMed

Sigma factor

• SigM PubMed

References

Reviews

Loading

Original publications

Loading