trigger enzyme, hypoxanthine phosphoribosyltransferase and part of a transcription activator
function
purine salvage and interconversion, control of ftsH expression
product
hypoxanthine phosphoribosyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.3|Purine salvage and interconversion][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.7|Control of transcription factor (other than two-component system)][category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.3|Targets of (p)ppGpp][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|transcription factors and their control], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|SigM regulon]Gene
Coordinates on the chromosome (coding sequence)
76,344 -> 76,886
Phenotypes of a mutant
essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]The protein
Catalyzed reaction/ biological activity
IMP diphosphate = hypoxanthine 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)Protein family
purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)Effectors of protein activity
inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´[Pubmed|22981860]Structure
[PDB|1J7J] (from ''Salmonella typhimurium'', 51% identity, 73% similarity)[SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|TilS]-[protein|search|HprT], the complex activates transcription of ''[protein|search|ftsH]'' [Pubmed|24001521]Expression and Regulation
Operon
''[protein|search|tilS]-[protein|search|hprT]-[protein|search|ftsH]'' [Pubmed|18179421][SW|Sigma factor]
[protein|search|SigM] [Pubmed|18179421]References
Reviews
Original publications
18179421,22981860,24001521,6408059,28189581 
