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hprT [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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hprT [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

trigger enzyme,hypoxanthine phosphoribosyltransferase and part of a transcription activator
Locus
BSU00680
Isoelectric point
4.00
Molecular weight
20.00 kDa
Function
purine salvage and interconversion, control of ftsH expression
Product
hypoxanthine phosphoribosyltransferase
Essential
yes
E.C.
2.4.2.8
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Purine salvage and interconversion
  • Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
  • Information processing → Regulation of gene expression → Transcription factors and their control → Control of transcription factor (other than two-component system)
  • Information processing → Targets of second messengers → Targets of (p)ppGpp
  • Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)

    • Categories containing this gene/protein

  • biosynthesis/ acquisition of nucleotides, transcription factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes

    • This gene is a member of the following regulons

  • SigM regulon

    • Gene

    Coordinates on the chromosome (coding sequence)
    76,344 -> 76,886

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • IMP diphosphate = hypoxanthine 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

    • Protein family

  • purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)

    • Effectors of protein activity

  • inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´PubMed

    • Structure

  • 1J7J (from Salmonella typhimurium, 51% identity, 73% similarity)

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Interactions

  • TilS-HprT, the complex activates transcription of ftsH PubMed

    • Expression and Regulation

    Operon

  • tilS-hprT-ftsH PubMed

    • Sigma factor

  • SigM PubMed

    • References

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