dfrA [Mon Aug 31 2015 13:55:09 GMT+0200 (CEST)]

dihydrofolate reductase

locus: BSU21810

pI: 5.22

mw: 19.00 kDa

function: biosynthesis of folate

product: dihydrofolate reductase

essential: yes

ec: 1.5.1.3

synonyms: tmp

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

syns: tmp

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors], [SW|essential genes]

Gene

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• 5,6,7,8-tetrahydrofolate + NADP⁺ = 7,8-dihydrofolate + NADPH (according to Swiss-Prot)

Protein family

• spmB family (according to Swiss-Prot)

Structure

• [PDB|1ZDR] (Geobacillus stearothermophilus)

[SW|Interactions]

• [protein|search|DfrA]-[protein|search|ThyB]

Expression and Regulation

Operon

• ''[protein|search|thyB]-[protein|search|dfrA]'' [Pubmed|2840350]

References

• 2840350,6436144,3918568,24158440