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dfrA
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dfrA

dihydrofolate reductase
Locus
BSU_21810
Isoelectric point
5.22
Molecular weight
19.03 kDa
Protein length
168 aa Sequence Blast
Gene length
507 bp Sequence Blast
Function
biosynthesis of folate
Product
dihydrofolate reductase
Essential
yes
E.C.
1.5.1.3
Synonyms
tmp
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of folate
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    2,296,603 → 2,297,109

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • (6S)-5,6,7,8-tetrahydrofolate + NADP+ --> 7,8-dihydrofolate + H+ + NADPH (according to UniProt)

    • Protein family

  • dihydrofolate reductase family (single member, according to UniProt)

    • Domains

  • DHFR domain (aa 1-159) (according to UniProt)

    • Structure

  • 1ZDR (Geobacillus stearothermophilus)

    • Expression and Regulation

    Operons

    Genes
    ypjP-ypjQ-thyB-dfrA-ypkP
    Description
    PubMed
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    Genes
    thyB-dfrA
    Description
    PubMed

    Regulatory mechanism

  • CcpN: activation, weak, in CcpN regulon

    • Regulation

  • weak induction in the presence of glucose (CcpN) PubMed
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    References

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