inorganic polyphosphate/ATP-NAD kinase
function
generation of NADP from NAD
product
inorganic polyphosphate/ATP-NAD kinase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors]Gene
Coordinates on the chromosome (coding sequence)
3,021,233 -> 3,022,036
The protein
Catalyzed reaction/ biological activity
ATP + NAD+ = ADP + NADP+ (according to Swiss-Prot)Protein family
NAD kinase family (according to Swiss-Prot)Structure
[PDB|1YT5] (from ''Thermotoga maritima'') [Pubmed|16511117][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|ytdI]'' [Pubmed|21815947]Regulatory mechanism
[protein|search|RoxS]: inhibition of translation and initiation of RNA degradation by [rny|search|RNase Y] and [rnc|search|RNase III] [Pubmed|25643072]Additional information
the mRNA base-pairs with the [protein|search|RoxS] [protein|search|sRNA] [PubMed|25643072]half-life of the mRNA: 8.4 min, in a '[protein|search|roxS]' mutant 15 min, in a '[protein|search|rny]' mutant 24 min [PubMed|25643072]the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]the '[protein|search|roxS]'-'[protein|search|ppnKB]' RNA duplex forms a cleavage site for [rnc|search|RNase III] [PubMed|25643072]two pathways of mRNA degradation: (i) by [rny|search|RNase Y], (ii) by combined action of [protein|search|RoxS] and [rnc|search|RNase III] [PubMed|25643072]References
16511117,25643072,21815947 
