resistance against oxidative stress and cell wall antibiotics, membrane anchor for LiaH
function
resistance against oxidative stress and cell wall antibiotics
product
membrane anchor for LiaH
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|LiaR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,398,550 -> 3,398,930
The protein
[SW|Localization]
cell membrane [Pubmed|24666271]forms highly dynamic membrane-associated foci under non-inducing conditions [Pubmed|24666271]co-localizes with [protein|search|LiaH] in distinct static spots at the cytoplasma membrane under stress conditions [Pubmed|24666271][SW|Interactions]
[protein|search|LiaI]-[protein|search|LiaH] [Pubmed|24666271]Expression and Regulation
Operon
''[protein|search|liaI]-[protein|search|liaH]-[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|14651641]''[protein|search|liaI]-[protein|search|liaH]'' [Pubmed|20639339][SW|Sigma factor]
[protein|search|SigA] [Pubmed|15273097]Regulation
induced by bacitracin and rhamnolipids ([protein|search|LiaR]) [Pubmed|16816187,22092710]repressed during logarithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed], indirect regulation by [protein|search|AbrB] [Pubmed|20817675]repressed by glucose (4.3-fold) [Pubmed|12850135]Regulatory mechanism
[protein|search|LiaR]: transcription activation [Pubmed|16816187]Biological materials
Mutant
1A980 ( ''liaI''::''erm''), [Pubmed|15273097], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A980&Search=1A980 BGSC]References
Reviews
Original publications
19164152,15273097,17660417,17600057,20057163,16816187,15101989,17660417,12850135,16816187,20639339,20817675,22092710,24666271 
