liaI [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

resistance against oxidative stress and cell wall antibiotics, membrane anchor for LiaH

Locus: BSU33130

Isoelectric point: 9.00

Molecular weight: 13.00 kDa

Function: resistance against oxidative stress and cell wall antibiotics

Product: membrane anchor for LiaH

Essential: no

Synonyms: yvqI

Genomic Context

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Categories containing this gene/protein

• Lifestyles → Coping with stress → Resistance against toxins/ antibiotics
• Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

• LiaR regulon

Gene

Coordinates on the chromosome (coding sequence): 3,398,550 -> 3,398,930

The protein

Localization

• cell membrane PubMed
• forms highly dynamic membrane-associated foci under non-inducing conditions PubMed
• co-localizes with LiaH in distinct static spots at the cytoplasma membrane under stress conditions PubMed

Interactions

• LiaI-LiaH PubMed

Expression and Regulation

Operon

• liaI-liaH-liaG-liaF-liaS-liaR PubMed
• liaI-liaH PubMed

Sigma factor

• SigA PubMed

Regulation

• induced by bacitracin and rhamnolipids (LiaR) PubMed
• repressed during logarithmic growth (AbrB) PubMed, indirect regulation by AbrB PubMed
• repressed by glucose (4.3-fold) PubMed

Regulatory mechanism

• LiaR: transcription activation PubMed

Biological materials

Mutant

• 1A980 ( liaI::erm), PubMed, available at BGSC

References

Reviews

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Original publications

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