divIB [Wed Feb 24 2016 14:01:37 GMT+0100 (CET)]

cell-division initiation protein (septum formation)

locus: BSU15240

pI: 9.00

mw: 30.00 kDa

function: septum formation

product: cell-division protein

essential: yes

synonyms: dds, tms-12

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|cell division], [SW|sporulation proteins], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|SigE regulon], [SW|SigM regulon], [SW|SpoIIID regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,593,704 -> 1,594,495

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Protein family

• ftsQ family (according to Swiss-Prot)

Structure

• [PDB|2ALJ] (major extracytoplasmic domain, Geobacillus stearothermophilus)

[SW|Localization]

• cell membrane [Pubmed|9426141]

[SW|Interactions]

• [protein|search|PbpB]-[SW|DivIB]-([protein|search|FtsL]-[SW|DivIC])2 [Pubmed|20870765], as part of the [SW|divisome]
• [protein|search|WalK]-[SW|DivIB] [Pubmed|21219466]

Expression and Regulation

[SW|Sigma factor]

• ''[SW|spoVE]'': [protein|search|SigE] [Pubmed|8320223]
• ''[protein|search|murG]'': [protein|search|SigM][Pubmed|18179421]
• ''[SW|divIB]'': [protein|search|SigA] [Pubmed|8106328]

Biological materials

FLAG-tag construct

• GP2005 ''divIB-3xFLAG ermC'' (based on [SW|pGP1087]), available in [SW|Jörg Stülke]'s lab

References

• 8459777,10852898,19429628,1391053,21219466,8320223,8106328,18179421,15659156,16936019,10217758,10792716,9720875,16936026,9426141,9044263