transcriptional repressor of anaerobically expressed genes involved in anaerobic respiration and fermentation
function
regulation of fermentation and anaerobic respiration
product
transcriptional repressor
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.1|Regulators of electron transport][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.1|Carbon core metabolism] → [category|SW 2.2.1.5|Overflow metabolism][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|regulators of electron transport], [SW|carbon core metabolism], [SW|transcription factors and their control], [SW|sporulation/ other]Gene
Coordinates on the chromosome (coding sequence)
647,091 -> 647,738
Phenotypes of a mutant
inactivation of ''[SW|rex]'' reduces sporulation efficiency to 9.2% that of wild type cells [Pubmed|26735940]The protein
Protein family
transcriptional regulatory rex family (according to Swiss-Prot)Effectors of protein activity
NADH (indication of low oxygen concentration) releases Rex from DNA [Pubmed|18485070], Rex has a very highh affinity for NADHStructure
[PDB|2VT2], [PDB|2VT3][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|ydiG]-[protein|search|rex]-[SW|tatAY]-[SW|tatCY]'' [Pubmed|22383849]Biological materials
Mutant
LUW292 (erm), GP834 (erm), both available in the [SW|Stülke] labLabs working on this gene/protein
[SW|Claes von Wachenfeldt], Lund University, Sweden [http://aron.ldc.lu.se/kundwebb/cellorg/mibiol/research/wachen/index.htm Homepage]References
Reviews
Original publications
16207915,18485070,15231791,17015645,20525796,21402078,22383849,25216269,26735940 
