hydroxyethylthiazole phosphate biosynthesis
function
biosynthesis of thiamine
product
thiamin thiazole synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|Thi-box]Gene
Coordinates on the chromosome (coding sequence)
1,245,041 -> 1,245,811
The protein
Protein family
thiG family (according to Swiss-Prot)Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705], [Pubmed|17726680]Structure
[PDB|1XM3], [PDB|1TYG] (complex with [protein|search|ThiS]) [Pubmed|15362849][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|ThiS]-[protein|search|ThiG] [Pubmed|15362849]Expression and Regulation
Operon
''[protein|search|tenA]-[protein|search|tenI]-[protein|search|thiO]-[protein|search|thiS]-[protein|search|thiG]-[protein|search|thiF]-[protein|search|thiD]'' [Pubmed|1898926]Regulation
repressed by thiamine ([protein|search|Thi-box]) [Pubmed|16356850]Regulatory mechanism
[protein|search|Thi-box]: [SW|RNA switch] [Pubmed|16356850]References
Reviews
Original publications
15362849,17726680,16493705,19216519,14567704 
