function
fatty acid degradation
product
acyl-CoA dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|utilization of lipids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|FadR regulon], [SW|SdpR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,367,040 -> 3,368,824
The protein
Catalyzed reaction/ biological activity
Acyl-CoA ETF = 2,3-dehydroacyl-CoA reduced ETF (according to Swiss-Prot) Protein family
acyl-CoA dehydrogenase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YngJ], [protein|search|MmgC], [protein|search|AcdA]Structure
[PDB|2Z1Q] (from ''Thermus thermophilus hb8'', 52% identity, 68% similarity)[SW|Localization]
cell membrane [Pubmed|18763711]Expression and Regulation
Operon
''[protein|search|fadM]-[protein|search|fadN]-[protein|search|fadA]-[protein|search|fadE]'' [Pubmed|17189250]''[protein|search|fadN]-[protein|search|fadA]-[protein|search|fadE]'' [Pubmed|17189250][SW|Sigma factor]
''[protein|search|fadN]'': [protein|search|SigA] [Pubmed|17189250]Regulation
''[protein|search|fadN]'': induced by long-chain fatty acids ([protein|search|FadR]) [Pubmed|17189250]''[protein|search|fadN]'': subject to carbon catabolite repression ([protein|search|CcpA]-[PtsH|search|HPr(Ser-P)] [Pubmed|21398533]strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]Regulatory mechanism
[protein|search|FadR]: transcription repression [Pubmed|17189250][protein|search|SdpR]: transcription activation [Pubmed|12817086][protein|search|CcpA]-[PtsH|search|HPr(Ser-P)]: transcription repression [Pubmed|21398533]Biological materials
Mutant
BKE32820 (''[protein|search|fadE]''::''erm'', available in the BGSC, in [SW|Fabian Commichau]'s, and in [SW|Jörg Stülke]'s lab)References
17189250,12817086,18763711,23033921,21398533 
