ansZ [Tue Nov 01 2016 10:33:14 GMT+0100 (CET)]

asparaginase

Locus: BSU02690

Isoelectric point: 6.00

Molecular weight: 39.00 kDa

Function: asparagine utilization

Product: asparaginase

Essential: no

E.C.: 3.5.1.1

Synonyms: yccC

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Utilization of amino acids → Utilization of asparagine/ aspartate

Categories containing this gene/protein

• utilization of amino acids

This gene is a member of the following regulons

• CodY regulon, TnrA regulon

Gene

Coordinates on the chromosome (coding sequence): 290,915 -> 292,042

The protein

Catalyzed reaction/ biological activity

• L-asparagine H₂O = L-aspartate NH₃ (according to Swiss-Prot)

Protein family

• asparaginase 1 family (according to Swiss-Prot)

Paralogous protein(s)

• AnsA

Structure

• 1ZCF (from Pectobacterium atrosepticum scri1043, 55% identity, 73% similarity)

Interactions

• forms tetramers

Expression and Regulation

Operon

• ansZ PubMed

Sigma factor

• SigA PubMed

Regulation

• expressed in the absence of good nitrogen sources (glutamine or ammonium) (TnrA) PubMed
• repressed during growth in the presence of branched chain amino acids (CodY) PubMed

Regulatory mechanism

• TnrA: transcription activation PubMed
• CodY: transcription repression PubMed

References

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