nos [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

nitric-oxide synthase

locus: BSU07630

pI: 5.00

mw: 38.00 kDa

function: production of nitric oxide

product: nitric-oxide synthase

essential: no

synonyms: yflM

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]

[SW|Categories] containing this gene/protein

• [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]

Gene

Coordinates on the chromosome (coding sequence): 836,653 -> 837,744

The protein

Catalyzed reaction/ biological activity

• NADPH-dependent oxidation of l-arginine into l-citrulline [Pubmed|25826316]

Protein family

• Bacterial NOS oxygenase subfamily (according to Swiss-Prot)

[SW|Cofactors]

• heme b [Pubmed|20006999]
• NADPH [Pubmed|25826316]
• FMN or FAD [Pubmed|21635694]

Structure

• [PDB|2AMO] (loose dimer), [PDB|1M7V] (bound to tetrahydrofolate and arginine)

[SW|Interactions]

• [protein|search|Nos]-[protein|search|YkuN] (electron transfer from to [protein|search|Nos]) [Pubmed|25194416]

Expression and Regulation

Operon

• ''[protein|search|nos]-[protein|search|yflK]'' (according to [http://dbtbs.hgc.jp/COG/prom/yflMK.html DBTBS])

Additional information

• Note that the gene '[protein|search|yflL]' is located between '[protein|search|nos]' and '[protein|search|yflK]', but on the opposite strand.

References

Reviews

• 9818193

Original publications

• 12220171,11856757,20006999,21599925,22119809,23943262,21310962,21921039,25194416,25826316,26062720