ndk [Tue May 03 2016 10:03:48 GMT+0200 (CEST)]

nucleoside diphosphate kinase

locus: BSU22730

pI: 5.00

mw: 16.00 kDa

function: maintainance of an equilibrium between the
concentrations of different nucleoside triphosphates

product: nucleoside diphosphate kinase

essential: no

ec: 2.7.4.6

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.4|Nucleotide metabolism/ other]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]

[SW|Categories] containing this gene/protein

• [SW|nucleotide metabolism/ other], [SW|phosphoproteins]

Gene

Coordinates on the chromosome (coding sequence): 2,381,354 -> 2,381,803

Phenotypes of a mutant

• inactivation of ''[SW|ndk]'' reduces sporulation efficiency to 13.4% that of wild type cells [Pubmed|26735940]

The protein

Catalyzed reaction/ biological activity

• ATP nucleoside diphosphate = ADP nucleoside triphosphate (according to Swiss-Prot)

Protein family

• phosphate acetyltransferase and butyryltransferase family (according to Swiss-Prot)

Modification

• phosphorylation on Thr-92 AND Ser-123 [Pubmed|17218307]

Structure

• [PDB|1WKJ] (from ''Thermus thermophilus'', 59% identity, 82% similarity)

References

• 17218307,26735940