ndk [2017-8-11 16:0:3]

nucleoside diphosphate kinase

locus: BSU22730

pI: 5.57

mw: 16.82 kDa

protein length: 149 aa

gene length: 447 bp

function: maintainance of an equilibrium between the concentrations of different nucleoside triphosphates

product: nucleoside diphosphate kinase

essential: no

ec: 2.7.4.6

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.4|Nucleotide metabolism/ other]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]

Gene

Coordinates: 2,381,354 → 2,381,803

Phenotypes of a mutant

• inactivation of ''[gene|B498ED03F19B7A73878D5C947C28C2A87CAB934D|ndk]'' reduces sporulation efficiency to 13.4% that of wild type cells [Pubmed|26735940]

The protein

Catalyzed reaction/ biological activity

• ATP + nucleoside diphosphate = ADP + nucleoside triphosphate (according to Swiss-Prot)

Protein family

• phosphate acetyltransferase and butyryltransferase family (according to Swiss-Prot)

Modification

• phosphorylation on Thr-92 AND Ser-123 [Pubmed|17218307]

Structure

• [PDB|1WKJ] (from ''Thermus thermophilus'', 59% identity, 82% similarity)

Expression and Regulation

Operons

• genes: [gene|C45A5935559F0DAAD70F808725AF730BC18A2B0A|hepS]-[gene|DDD40AEBBCBD3C19661A72B85912E266DBF267B3|menH]-[gene|3CAEA54E80A0B56EE120B881C8CDBE055AF6BDC1|hepT]-[gene|B498ED03F19B7A73878D5C947C28C2A87CAB934D|ndk]
  description: [pubmed|22383849]

• genes: [gene|B498ED03F19B7A73878D5C947C28C2A87CAB934D|ndk]
  description: [pubmed|22383849]

References

• 17218307,26735940