mhqP

may be involved in protection against methyl-hydroquinone

locus: BSU_05500

pI: 8.62

mw: 13.14 kDa

protein length: 129 aa

gene length: 390 bp

function: may be involved in protection against methyl-hydroquinone

product: unknown

essential: no

synonyms: ydfP

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

Gene

Coordinates: 598,154 → 598,543

The protein

Protein family

• DoxX family (with [protein|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|CatD], according to UniProt)

Expression and Regulation

Operons

• genes: [gene|ACAFB2072E74CC059B492A31EF492028B96C569F|mhqO]-[gene|B4384C8C0874BAA7822E9B6DCAB57790018271D8|mhqP]
  description: [Pubmed|11532142]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17725564], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|11532142], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

  regulatory mechanism

  • [protein|997B828A99D6D8460712C18ED0CE566B285C22DC|MhqR]: repression, [Pubmed|17725564], in [regulon|997B828A99D6D8460712C18ED0CE566B285C22DC|MhqR regulon]

  regulation

  • induced by catechol and 2-methylhydroquinone ([protein|search|MhqR]) [Pubmed|17725564]

• genes: [gene|A0842DD5F1B13AC15C95F18751E7836DF31B262A|mhqN]-[gene|ACAFB2072E74CC059B492A31EF492028B96C569F|mhqO]-[gene|B4384C8C0874BAA7822E9B6DCAB57790018271D8|mhqP]
  description: [Pubmed|17725564]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17725564], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|997B828A99D6D8460712C18ED0CE566B285C22DC|MhqR]: repression, [Pubmed|17725564], in [regulon|997B828A99D6D8460712C18ED0CE566B285C22DC|MhqR regulon]

  regulation

  • induced by catechol and 2-methylhydroquinone ([protein|search|MhqR]) [Pubmed|17725564]

Biological materials

Mutant

• MGNA-C169 (ydfP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2167 NBRP B. subtilis, Japan]
• BKE05500 (Δ[gene|B4384C8C0874BAA7822E9B6DCAB57790018271D8|mhqP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE05500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGTATCTCTCCTCATC, downstream forward: _UP4_TAATACGAAAGTATGTAAGA
• BKK05500 (Δ[gene|B4384C8C0874BAA7822E9B6DCAB57790018271D8|mhqP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK05500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGTATCTCTCCTCATC, downstream forward: _UP4_TAATACGAAAGTATGTAAGA

References

• 17407181,17725564,11532142,27965289