SEDS family peptidoglycan glycosyltransferase, control of cell shape and elongation
function
control of cell shape and elongation
product
SEDS family peptidoglycan glycosyltransferase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.2|Cell shape][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell shape], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigM regulon]Gene
Coordinates on the chromosome (coding sequence)
3,912,332 -> 3,913,513
Phenotypes of a mutant
essential [Pubmed|12682299]CRISPRi knockdown mutant has a terminal phenotype of severe lysis [Pubmed|27238023]The protein
Catalyzed reaction/ biological activity
principal peptidoglycan glycosyltransferase of the [SW|elongasome] [Pubmed|27525505]Protein family
[SW|FtsW]/[SW|RodA]/[SW|SpoVE] family (according to Swiss-Prot)[SW|SEDS proteins] (shape, elongation, division, and sporulation)Paralogous protein(s)
[protein|search|FtsW], [SW|SpoVE][SW|Localization]
integral membrane protein [Pubmed|21636744]forms circumferentially moving patches [Pubmed|21636744]localization depends on [SW|MreB] [SW|26679002][SW|Interactions]
part of the [SW|elongasome] [Pubmed|21636744,21636745]Expression and Regulation
Operon
''rodA'' [Pubmed|9353933][SW|Sigma factor]
[protein|search|SigM] [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 Pubmed]Biological materials
Mutant
xylose-inducible CRISPRi knockdown mutant BEC38120 is available from the [http://subtiwiki.uni-goettingen.de/wiki/index.php/Daniel_R._Zeigler BGSC]Labs working on this gene/protein
[SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage][SW|David Rudner], Harvard Medical School, MA, USA [http://rudnerlab.med.harvard.edu/ homepage]References
Reviews
Original Publications
27525505, 27238023, 9622350,21636744,21636745,17981970 
