SubtiBank SubtiBank
coaA
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coaA

type I pantothenate kinase, major enzyme
Locus
BSU_23760
Isoelectric point
5.89
Molecular weight
36.49 kDa
Protein length
319 aa Sequence Blast
Gene length
960 bp Sequence Blast
Function
biosynthesis of coenzyme A
Product
pantothenate kinase
Essential
no
E.C.
2.7.1.33
Synonyms
yqjS
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of coenzyme A

    • Gene

    Coordinates
    2,468,549 → 2,469,508

    The protein

    Catalyzed reaction/ biological activity

  • (R)-pantothenate + ATP --> (R)-4'-phosphopantothenate + ADP + H+ (according to UniProt)

    • Protein family

  • prokaryotic pantothenate kinase family (single member, according to UniProt)

    • Structure

  • 1SQ5 (from Escherichia coli, 49% identity, 67% similarity) PubMed

    • Expression and Regulation

    Operons

    Genes
    yqjP-yqjQ-dsdA-coaA-yqjT
    Description
    PubMed
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    Biological materials

    Mutant

  • MGNA-C399 (yqjS::erm), available at the NBRP B. subtilis, Japan
  • BKE23760 (ΔcoaA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACTGTTTACACCTGACTCT, downstream forward: _UP4_GTGTTGGTAAGGAGGGTATG
  • BKK23760 (ΔcoaA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACTGTTTACACCTGACTCT, downstream forward: _UP4_GTGTTGGTAAGGAGGGTATG

    • References

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