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efeO [2017-06-14 15:56:23]
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efeO [2017-06-14 15:56:23]

lipoprotein, elemental iron uptake system (binding protein), high affinity uptake of ferric iron (Fe(III))
Locus
BSU38270
Isoelectric point
4.71
Molecular weight
42.63 kDa
Protein length
385 aa Sequence Blast
Gene length
1155 bp Sequence Blast
Function
elemental iron uptake
Product
elemental iron uptake system (binding protein)
Essential
no
Synonyms
ywbM
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Transporters → Transporters/ other → Metal ion transporter
  • Cellular processes → Homeostasis → Acquisition of iron → Elemental iron transport system
  • Metabolism → Additional metabolic pathways → Iron metabolism → Elemental iron transport system
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    3,927,951 → 3,929,108

    The protein

    Catalyzed reaction/ biological activity

  • binds ferric iron (Fe(III)) with strong selectivity PubMed

    • Protein family

  • UPF0409 family (according to Swiss-Prot)

    • Structure

  • 3AT7 (from Sphingomonas sp., 40% identity) PubMed

    • Localization

  • membrane PubMed
  • extracytosolic lipoprotein PubMed

    • Expression and Regulation

    Operons

    Genes
    efeU-efeO-efeB
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigM: sigma factor, PubMed, in SigM regulon
  • SigW: sigma factor, PubMed, in SigW regulon
  • SigX: sigma factor, in SigX regulon

    • Regulatory mechanism

  • Fur: repression, PubMed, in Fur regulon

    • Regulation

  • immediately induced upon iron starvation (first wave to allow iron uptake) (Fur) PubMed
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    Biological materials

    Mutant

  • MGNA-B227 (ywbM::erm), available at the NBRP B. subtilis, Japan

    • References

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