lipoprotein, elemental iron uptake system (binding protein), high affinity uptake of ferric iron (Fe(III))
function
elemental iron uptake
product
elemental iron uptake system (binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.2|Elemental iron transport system][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.5|Elemental iron transport system][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|acquisition of iron], [SW|iron metabolism], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|Fur regulon]Gene
Coordinates on the chromosome (coding sequence)
3,927,951 -> 3,929,108
The protein
Catalyzed reaction/ biological activity
binds ferric iron (Fe(III)) with strong selectivity [Pubmed|23764491]Protein family
UPF0409 family (according to Swiss-Prot)Structure
[PDB|3AT7] (from ''Sphingomonas sp.'', 40% identity) [Pubmed|21238429][SW|Localization]
membrane [Pubmed|18763711]extracytosolic lipoprotein [Pubmed|23764491][SW|Interactions]
[protein|search|EfeO]-[protein|search|EfeU]-[protein|search|EfeB] [Pubmed|23180473,23764491]Expression and Regulation
Operon
''[protein|search|efeU]-[protein|search|efeO]-[protein|search|efeB]'' [Pubmed|9353933][SW|Sigma factor]
[protein|search|SigA] [Pubmed|23764491]Regulation
induced upon iron starvation ([protein|search|Fur]) [Pubmed|12354229]Regulatory mechanism
[protein|search|Fur]: transcription repression [Pubmed|12354229]References
16672620,9353933,12354229,18763711,23180473,23764491,21238429,27795321 
