function
heme biosynthesis
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors], [SW|sporulation proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|ResD regulon], [SW|SigE regulon]Gene
Coordinates on the chromosome (coding sequence)
1,558,034 -> 1,558,954
The protein
Catalyzed reaction/ biological activity
heme A synthesis from protoheme IX (heme B)Protein family
COX15/ctaA family, Type 1 subfamily (according to Swiss-Prot)[SW|Domains]
contains 8 transmembrane segments[SW|Cofactors]
heme B[SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''ctaA'' [Pubmed|2549007][SW|Sigma factor]
[protein|search|SigA] [Pubmed|11325953], [protein|search|SigE] [Pubmed|2549007,11325953]Regulation
expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10972837,11325953]Regulatory mechanism
[protein|search|ResD]: transcription activation [Pubmed|10972837,11325953]References
Reviews
Original publications
15576792,7961419,16321940,11325953,18358840,7968515,15491161,10972837,8665949,10972837,2549007,19174544,26592143 
