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ahpA [2019-09-04 10:36:27]
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ahpA [2019-09-04 10:36:27]

alkyl hydroperoxide reductase
locus
BSU_14220
pI
4.49
mw
20.30 kDa
protein length
180 aa Sequence Blast
gene length
543 bp Sequence Blast
function
protection against peroxide stress
product
alkyl hydroperoxide reductase
essential
no
synonyms
ykuU
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.4|Electron transport/ other/ based on similarity]

    • Gene

    Coordinates
    1,492,261 → 1,492,803

    The protein

    Catalyzed reaction/ biological activity

  • [protein]-dithiol + hydroperoxide --> [protein]-disulfide + alcohol + H2O (according to UniProt)

    • Protein family

  • [SW|peroxiredoxin family] (according to UniProt)

    • Paralogous protein(s)

  • [protein|D0982500E52577D52FADF775C0E512A4B9657B79|AhpC]

    • Structure

  • [PDB|4XCS] (human peroxiredoxin, 48% identity)

    • Expression and Regulation

    Operons

    genes
    [gene|B283B702D917E310130BC33A40BF6A5853C3D4C1|ahpA]-[gene|398E6FAC317D9BD81FB80A7CC9DF1CC757F2FA98|ahpT]
    description
    [Pubmed|20817675]

    regulatory mechanism

  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|20817675], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]
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    Biological materials

    Mutant

  • GP1729 [gene|search|ahpAT]::kan trpC2 available at Jörg Stülkes lab
  • MGNA-B343 (ykuU::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1342 NBRP B. subtilis, Japan]
  • BKE14220 (Δ[gene|B283B702D917E310130BC33A40BF6A5853C3D4C1|ahpA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTATCCCTCCAATTT, downstream forward: _UP4_TAATTCTTTCCAAGAACGAA
  • BKK14220 (Δ[gene|B283B702D917E310130BC33A40BF6A5853C3D4C1|ahpA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGTATCCCTCCAATTT, downstream forward: _UP4_TAATTCTTTCCAAGAACGAA

    • References

  • 20817675,26787766,27683249