SubtiBank SubtiBank
spoVAC
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spoVAC

mechanosensitive channel, essential for the uptake of the 1:1 chelate of pyridine-2,6-dicarboxylic acid (DPA(2,6)) and Ca(2 ) into developing spores, required for spore maturation
Locus
BSU_23420
Isoelectric point
9.46
Molecular weight
15.97 kDa
Protein length
150 aa Sequence Blast
Gene length
453 bp Sequence Blast
Function
spore maturation
Product
mechanosensitive channel
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other
  • Lifestyles → Coping with stress → Coping with hypo-osmotic stress
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    2,441,804 → 2,442,256

    The protein

    Localization

  • inner spore membrane PubMed

    • Expression and Regulation

    Operons

    Genes
    spoVAA-spoVAB-spoVAC-spoVAD-spoVAEB-spoVAEA-spoVAF-lysA
    Description
    PubMed

    Sigma factors

  • SigG: sigma factor, PubMed, in SigG regulon

    • Regulatory mechanism

  • SpoVT: activation, PubMed, in SpoVT regulon

    • Regulation

  • expressed late during sporulation in the forespore (SigG, SpoVT) PubMed
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    Biological materials

    Mutant

  • BKE23420 (ΔspoVAC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCTTGAAACCTCCTTATG, downstream forward: _UP4_CTGATGTCATAGGAGGAGAA
  • BKK23420 (ΔspoVAC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCTTGAAACCTCCTTATG, downstream forward: _UP4_CTGATGTCATAGGAGGAGAA

    • Labs working on this gene/protein

  • Peter Setlow, University of Connecticut Health Center, USA

    • References

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