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adhR
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adhR

transcriptional activator ([SW|MerR family]) of [gene|352544F3E79943E94E28A6EB5F4C543B529A02D1|adhA]-[gene|0960F1856A81237DBA6AF1FAF36172A63ECBE2D5|yraA], responsive to formaldehyde and methylglyoxal
locus
BSU_27000
pI
9.64
mw
16.30 kDa
protein length
140 aa Sequence Blast
gene length
423 bp Sequence Blast
function
regulation of the protective response to formaldehyde and methylglyoxal
product
transcriptional activator ([SW|MerR family])
essential
no
synonyms
yraB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

    • Gene

    Coordinates
    2,755,382 → 2,755,804

    The protein

    Protein family

  • [SW|MerR family]

    • [SW|Domains]

  • [SW|HTH merR-type domain] (aa 1-69) (according to UniProt)

    • Modification

  • activity probably redox-controlled via thiol-(S)-alkylation at Cys-52 by aldehydes [Pubmed|19170879]

    • Structure

  • [PDB|3GP4] (from Listeria monocytogenes, 47% identity)

    • [SW|Localization]

  • cytoplasmic

    • Expression and Regulation

    Operons

    genes
    [gene|B24BA6ABCAF7325EC5F8B2655CA182FFC23395FD|adhR]
    description
    [pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-A238 (yraB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/238 NBRP B. subtilis, Japan]
  • BKE27000 (Δ[gene|B24BA6ABCAF7325EC5F8B2655CA182FFC23395FD|adhR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCTTCACCTCTCTAT, downstream forward: _UP4_TAGCATTCTTTGCGTGTGAA
  • BKK27000 (Δ[gene|B24BA6ABCAF7325EC5F8B2655CA182FFC23395FD|adhR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCTTCACCTCTCTAT, downstream forward: _UP4_TAGCATTCTTTGCGTGTGAA

    • labs

  • [SW|Haike Antelmann],University of Greifswald, Germany

    • References

  • 21722790