gyrA [Mon Oct 31 2016 10:40:59 GMT+0100 (CET)]

DNA gyrase (subunit A)

locus: BSU00070

pI: 5.00

mw: 91.00 kDa

function: DNA supercoiling,
initation of replication cycle and DNA elongation

product: DNA gyrase (subunit A)

essential: yes

ec: 5.99.1.3

synonyms: nalA

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|DNA condensation/ segregation], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence): 6,994 -> 9,459

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to Swiss-Prot)

Protein family

• topoisomerase gyrA/parC subunit family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|ParC]

Structure

• [PDB|4DDQ] (DNA gyrase A-subunit lacking the C-terminal DNA-wrapping domains) [Pubmed|23602808]

[SW|Localization]

• Nucleoid (Homogeneous) [Pubmed|16479537]
• nucleoid-associated in actively growing cells [Pubmed|9539793]

[SW|Interactions]

• [protein|search|GyrA]-[protein|search|GyrB]

Additional information

• subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]

Expression and Regulation

Operon

• ''gyrA'' [Pubmed|2987848]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|2987848]

Additional information

• subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]

Labs working on this gene/protein

• [SW|Dagmar Klostermeier], University of Münster, Germany, [http://www.biozentrum.unibas.ch/klostermeier/index.html homepage]

References

• 16479537,17981983,9539793,2987848,19666507,17320901,23475963,23602808,20870749,24563461,27557712