gyrA [2018-11-21 10:22:42]

DNA gyrase (subunit A)

Locus: BSU00070

Isoelectric point: 5.22

Molecular weight: 91.91 kDa

Protein length: 821 aa

Gene length: 2463 bp

Function: DNA supercoiling, control of replication initiation

Product: DNA gyrase (subunit A)

Essential: yes

E.C.: 5.99.1.3

Synonyms: nalA

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → DNA condensation/ segregation
• Groups of genes → Essential genes

Gene

Coordinates: 6,994 → 9,459

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to Swiss-Prot)
• decreases DnaA association with the oriC and inhibits replication initiation PubMed

Protein family

• topoisomerase IIA gyrA/parC subunit family (according to Swiss-Prot)

Paralogous protein(s)

• ParC

Structure

• 4DDQ (DNA gyrase A-subunit lacking the C-terminal DNA-wrapping domains) PubMed

Localization

• Nucleoid (Homogeneous) PubMed
• nucleoid-associated in actively growing cells PubMed

Additional information

• subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and Regulation

Operons

• Genes: yaaA-recF-remB-gyrB-gyrA
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

Labs working on this gene/protein

• Dagmar Klostermeier, University of Münster, Germany, homepage

References

Reviews

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Original publications

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