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gyrA [2018-11-21 10:22:42]
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gyrA [2018-11-21 10:22:42]

DNA gyrase (subunit A)
Locus
BSU00070
Isoelectric point
5.22
Molecular weight
91.91 kDa
Protein length
821 aa Sequence Blast
Gene length
2463 bp Sequence Blast
Function
DNA supercoiling, control of replication initiation
Product
DNA gyrase (subunit A)
Essential
yes
E.C.
5.99.1.3
Synonyms
nalA

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
6,994 → 9,459

Phenotypes of a mutant

  • essential PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to Swiss-Prot)
  • decreases DnaA association with the oriC and inhibits replication initiation PubMed
  • Protein family

  • topoisomerase IIA gyrA/parC subunit family (according to Swiss-Prot)
  • Paralogous protein(s)

    Structure

  • 4DDQ (DNA gyrase A-subunit lacking the C-terminal DNA-wrapping domains) PubMed
  • Localization

  • Nucleoid (Homogeneous) PubMed
  • nucleoid-associated in actively growing cells PubMed
  • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
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    Labs working on this gene/protein

  • Dagmar Klostermeier, University of Münster, Germany, homepage
  • References

    Reviews

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    Original publications

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