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tcyM [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
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tcyM [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

cystine ABC transporter (permease)
locus
BSU29350
pI
8.77
mw
25.00 kDa
function
cystine uptake
product
cystine ABC transporter (permease)
essential
no
synonyms
ytmM
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.2|Uptake of amino acids]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|CymR regulon], [SW|AscR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,005,122 -> 3,005,829

    The protein

    Protein family

  • binding-protein-dependent transport system permease family (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane [Pubmed|10092453]

    • [SW|Interactions]

  • [protein|search|TcyN]-([protein|search|TcyL]-[protein|search|TcyM])-([protein|search|TcyJ]-[protein|search|TcyK]) [Pubmed|10092453]

    • Expression and Regulation

    Operon

  • ''[protein|search|snaA]-[protein|search|tcyJ]-[protein|search|tcyK]-[protein|search|tcyL]-[protein|search|tcyM]-[protein|search|tcyN]-[protein|search|cmoO]-[protein|search|cmoI]-[protein|search|cmoJ]-[protein|search|ribR]-[protein|search|sndA]-[protein|search|ytnM]'' [Pubmed|15668000]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|15272571]

    • Regulation

  • repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16109943]
  • induced in the presence of S-methyl-cysteine ([protein|search|AscR]) [Pubmed|23944997]

    • Regulatory mechanism

  • [protein|search|CymR]: transcription repression [Pubmed|16109943]
  • [protein|search|AscR]: transcription activation [Pubmed|16109943]

    • Biological materials

    Mutant

  • 1A948 ( ''tcyM''::''kan''), [Pubmed|15262924], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A948&Search=1A948 BGSC]

    • References

  • 15262924,10092453,16109943,12193636,15668000,15272571,23944997