tcyM [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

cystine ABC transporter (permease)

Locus: BSU29350

Isoelectric point: 8.77

Molecular weight: 25.00 kDa

Function: cystine uptake

Product: cystine ABC transporter (permease)

Essential: no

Synonyms: ytmM

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → ABC transporters → Importers → Uptake of amino acids
• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of cysteine
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• ABC transporters, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

• CymR regulon, AscR regulon

Gene

Coordinates on the chromosome (coding sequence): 3,005,122 -> 3,005,829

The protein

Protein family

• binding-protein-dependent transport system permease family (according to Swiss-Prot)

Localization

• cell membrane PubMed

Interactions

• TcyN-(TcyL-TcyM)-(TcyJ-TcyK) PubMed

Expression and Regulation

Operon

• snaA-tcyJ-tcyK-tcyL-tcyM-tcyN-cmoO-cmoI-cmoJ-ribR-sndA-ytnM PubMed

Sigma factor

• SigA PubMed

Regulation

• repressed in the presence of cysteine (CymR) PubMed
• induced in the presence of S-methyl-cysteine (AscR) PubMed

Regulatory mechanism

• CymR: transcription repression PubMed
• AscR: transcription activation PubMed

Biological materials

Mutant

• 1A948 ( tcyM::kan), PubMed, available at BGSC

References

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