product
glycerol facilitator
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.3|Carbohydrate transporter][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.3|Utilization of glycerol/ glycerol-3-phosphate][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|utilization of specific carbon sources], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|CcpA regulon], [SW|GlpP regulon]Gene
Coordinates on the chromosome (coding sequence)
1,002,501 -> 1,003,325
The protein
Protein family
View classification (according to Swiss-Prot)Structure
[PDB|1FX8] (the protein from ''E. coli'', 37% identity)[SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|glpF]-[protein|search|glpK]'' [Pubmed|2127799][SW|Sigma factor]
[protein|search|SigA] [Pubmed|2127799]Regulation
repressed by glucose (8-fold) ([protein|search|CcpA]) [Pubmed|12850135]induction by glycerol ([protein|search|GlpP]) [Pubmed|8436953]strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|12850135][protein|search|GlpP]-dependent [SW|RNA switch] (transcriptional antitermination) [Pubmed|8436953][protein|search|AbrB]: transcription activation [Pubmed|20817675]Biological materials
Mutant
GP99 (cat) (available in [SW|Jörg Stülke]'s lab)References
12850135,8436953,11929549,23033921,22900538,20817675 
