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oppB [Mon May 30 2016 11:06:30 GMT+0200 (CEST)]
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oppB [Mon May 30 2016 11:06:30 GMT+0200 (CEST)]

oligopeptide ABC transporter (permease)
locus
BSU11440
pI
9.00
mw
33.00 kDa
function
initiation of sporulation, competence development
product
oligopeptide ABC transporter (permease)
essential
no
synonyms
spo0KB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.3|Uptake of peptides]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.4|Utilization of peptides]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|utilization of nitrogen sources other than amino acids], [SW|genetic competence], [SW|phosphorelay], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon], [SW|ScoC regulon], [SW|TnrA regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,221,594 -> 1,222,529

    The protein

    Catalyzed reaction/ biological activity

  • required for the uptake of quorum sensing peptides such as [protein|search|PhrH] [Pubmed|21908671]

    • Protein family

  • ABC transmembrane type-1 domain (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane [Pubmed|10092453,18763711]

    • [SW|Interactions]

  • ([protein|search|OppD]-[protein|search|OppF])-([protein|search|OppB]-[protein|search|OppC])-[protein|search|OppA] [Pubmed|10092453]

    • Expression and Regulation

    Operon

  • ''[protein|search|oppA]-[protein|search|oppB]-[protein|search|oppC]-[protein|search|oppD]-[protein|search|oppF]'' [Pubmed|1901616]

    • Regulation

  • expressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|12823818]
  • repressed during exponential growth ([protein|search|ScoC]) [Pubmed|10383984]

    • Regulatory mechanism

  • [protein|search|TnrA]: transcription activation [Pubmed|12823818]
  • [protein|search|ScoC]: transcription repression [Pubmed|10383984]
  • [protein|search|CodY]: transcription repression, no derepression occurs, however, in a ''[protein|search|codY]'' mutant, due to increased repression by [protein|search|ScoC] [Pubmed|25966844]

    • Biological materials

    Mutant

  • GP2063 (''[protein|search|oppB]''::''spc''), available in [SW|Jörg Stülke]'s lab
  • GP2097 (D(''[protein|search|oppA]-[protein|search|oppB]-[protein|search|oppC]-[protein|search|oppD]-[protein|search|oppF]'')::''aphA3''), available in [SW|Jörg Stülke]'s lab

    • References

  • 12823818,1901616,10092453,9252573,25966844,7997159,12823818,10383984,18763711,21908671,1899858,25755103