guanine deaminase, general stress protein, important for survival of ethanol and paraquat stresses
function
deamination of guanine to xanthine,
purine salvage and interconversion
product
guanine deaminase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.3|Purine salvage and interconversion][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress]This gene is a member of the following [SW|regulons]
[SW|PucR regulon], [SW|SigB regulon]Gene
Coordinates on the chromosome (coding sequence)
1,382,677 -> 1,383,147
The protein
Catalyzed reaction/ biological activity
Guanine + H2O = xanthine + NH3 (according to Swiss-Prot)Protein family
cytidine and deoxycytidylate deaminase family (according to Swiss-Prot)Structure
[PDB|1WKQ]Expression and Regulation
Operon
''guaD'' [Pubmed|11101664][SW|Sigma factor]
[protein|search|SigA] [Pubmed|11101664], [protein|search|SigB] [Pubmed|15805528]Regulation
induced by stress ([protein|search|SigB]) [Pubmed|15805528]induced in the presence of purine nucleotides (inducer: allantoin) ([protein|search|PucR]) [Pubmed|12029039]Regulatory mechanism
[protein|search|PucR]: transcription activation [Pubmed|12029039]References
11101664,12029039,15180998,15805528,11344136,22582280 
